Pharmacological targeting of spreading depression in migraine
نویسندگان
چکیده
منابع مشابه
P141: The Role of Microglia in Cortical Spreading Depression in Migraine
Migraine is a disorder that afflicts nearly one tenth of the population. Involving both nervous and vascular system, it has been found as a prominent factor of disability. The migraine attacks may be initiated in the brainstem or may begin peripherally in the meninges while the role of cortical activation preceding an attack is also debated. Although available treatments, more studies on migrai...
متن کاملFamilial Hemiplegic Migraine and Spreading Depression
OBJECTIVE Familial hemiplegic migraine (FHM) is an autosomal dominantly inherited subtype of migraine with aura, characterized by transient neurological signs and symptoms. Typical hemiplegic migraine attacks start in the first or second decade of life. Some patients with FHM suffer from daily recurrent attacks since childhood. Results from extensive studies of cellular and animal models have i...
متن کاملfamilial hemiplegic migraine and spreading depression
how to cite this article: kazemi h, speckmann ej, gorji a. familial hemiplegic migraine and spreading depression. iran j child neurol. 2014 summer;8(3): 6-11. abstract objective familial hemiplegic migraine (fhm) is an autosomal dominantly inherited subtype of migraine with aura, characterized by transient neurological signs and symptoms. typical hemiplegic migraine attacks start in the first...
متن کاملAre cortical spreading depression and headache in migraine causally linked?
During the past few decades, much controversy has surrounded the pathophysiology of migraine. Cortical spreading depression (CSD) is widely accepted as the neuronal process underlying visual auras. It has been proposed that CSD can also cause the headaches, at least in migraine with aura. We describe three patients, each fulfilling the International Headache Society criteria for migraine with a...
متن کامل[Cortical spreading depression and molecular genetics in migraine].
Cortical spreading depression (CSD) is a slowly propagated wave of depolarization of neurons and glial cells, followed by a subsequent sustained suppression of spontaneous neuronal activity. Functional imaging studies of migraine patients have shown dramatic changes in blood flow and brain activity whose characteristics are similar to those of CSD, implicated in migraine visual aura. Although t...
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ژورنال
عنوان ژورنال: Expert Review of Neurotherapeutics
سال: 2012
ISSN: 1473-7175,1744-8360
DOI: 10.1586/ern.12.13